CSK
C-terminal Src kinase

The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

Developmental clusters: GC2
Biological processes 47 terms
ATP binding (GO:0005524)T cell costimulation (GO:0031295)T cell receptor signaling pathway (GO:0050852)adherens junction organization (GO:0034332)adherens junction organization (GO:0034332)cell-cell junction (GO:0005911)cellular response to peptide hormone stimulus (GO:0071375)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)identical protein binding (GO:0042802)intracellular signal transduction (GO:0035556)negative regulation of ERK1 and ERK2 cascade (GO:0070373)negative regulation of Golgi to plasma membrane protein transport (GO:0042997)negative regulation of T cell activation (GO:0050868)negative regulation of T cell receptor signaling pathway (GO:0050860)negative regulation of bone resorption (GO:0045779)negative regulation of cell population proliferation (GO:0008285)negative regulation of interleukin-6 production (GO:0032715)negative regulation of low-density lipoprotein particle clearance (GO:0010989)negative regulation of phagocytosis (GO:0050765)non-membrane spanning protein tyrosine kinase activity (GO:0004715)non-membrane spanning protein tyrosine kinase activity (GO:0004715)oligodendrocyte differentiation (GO:0048709)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)proline-rich region binding (GO:0070064)protein binding (GO:0005515)protein binding (GO:0005515)protein kinase A catalytic subunit binding (GO:0034236)protein kinase activity (GO:0004672)protein phosphatase binding (GO:0019903)protein phosphorylation (GO:0006468)protein tyrosine kinase activity (GO:0004713)protein tyrosine kinase activity (GO:0004713)protein tyrosine kinase binding (GO:1990782)regulation of Fc receptor mediated stimulatory signaling pathway (GO:0060368)regulation of Fc receptor mediated stimulatory signaling pathway (GO:0060368)regulation of immune response (GO:0050776)regulation of multicellular organismal process (GO:0051239)transferase activity (GO:0016740)
Expression (TPM)
CSK — as a Regulated Gene

TFs regulating CSK 0 TFs

Transcription factors with Perturb-seq knockdown data for CSK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CSK

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr15:74,531,382–74,531,884 250.4 kb Distal (>10kb) Multiome 217
chr15:74,540,389–74,542,119 240.9 kb Distal (>10kb) Multiome 838
chr15:74,598,102–74,598,966 183.6 kb Distal (>10kb) Multiome 689
chr15:74,614,343–74,616,348 166.3 kb Distal (>10kb) Multiome HiCAR 1019
chr15:74,695,758–74,696,387 86.0 kb Distal (>10kb) Multiome 775
chr15:74,720,336–74,720,840 61.4 kb Distal (>10kb) Multiome 16
chr15:74,725,773–74,726,537 55.9 kb Distal (>10kb) Multiome 607
chr15:74,759,107–74,760,837 21.7 kb Distal (>10kb) Multiome 637
chr15:74,761,837–74,762,260 19.9 kb Distal (>10kb) Multiome 34
chr15:74,770,975–74,771,578 10.8 kb Distal (>10kb) Multiome 485
chr15:74,773,571–74,774,122 8.0 kb Proximal (<10kb) 107
chr15:74,777,213–74,777,634 4.4 kb Proximal (<10kb) 319
chr15:74,781,439–74,783,648 8 bp At TSS Multiome 679
chr15:74,787,636–74,788,037 5.6 kb Proximal (<10kb) 360
chr15:74,842,412–74,843,723 60.9 kb Distal (>10kb) Multiome 879
chr15:74,872,771–74,874,092 91.2 kb Distal (>10kb) Multiome 758
chr15:74,889,894–74,890,629 108.0 kb Distal (>10kb) Multiome 816
chr15:74,905,926–74,907,376 124.7 kb Distal (>10kb) Multiome 743
chr15:74,937,494–74,938,710 156.0 kb Distal (>10kb) Multiome 998
chr15:74,950,147–74,950,911 168.6 kb Distal (>10kb) Multiome 326
chr15:74,954,536–74,955,001 172.6 kb Distal (>10kb) Multiome 348
chr15:74,955,873–74,957,720 174.7 kb Distal (>10kb) Multiome 776
chr15:74,958,363–74,959,586 176.5 kb Distal (>10kb) Multiome 282
chr15:74,995,116–74,996,280 213.4 kb Distal (>10kb) Multiome 825
chr15:75,023,365–75,023,895 241.5 kb Distal (>10kb) Multiome 822

Genome Browser

Genomic view of the CSK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr15:74,521,382 – 75,033,895
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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