The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:56,006,888–56,008,461 | 292.7 kb | Distal (>10kb) Multiome | 745 | |
| chr12:56,020,644–56,021,511 | 279.4 kb | Distal (>10kb) Multiome | 364 | |
| chr12:56,041,220–56,042,537 | 258.5 kb | Distal (>10kb) Multiome | 1035 | |
| chr12:56,078,964–56,081,015 | 221.1 kb | Distal (>10kb) Multiome | 1032 | |
| chr12:56,103,918–56,105,302 | 195.9 kb | Distal (>10kb) Multiome | 977 | |
| chr12:56,115,844–56,117,060 | 183.8 kb | Distal (>10kb) Multiome | 958 | |
| chr12:56,117,641–56,119,301 | 182.1 kb | Distal (>10kb) Multiome | 1052 | |
| chr12:56,126,181–56,126,640 | 174.0 kb | Distal (>10kb) Multiome | 671 | |
| chr12:56,127,552–56,129,104 | 172.2 kb | Distal (>10kb) Multiome | 800 | |
| chr12:56,151,724–56,153,003 | 147.9 kb | Distal (>10kb) Multiome | 830 | |
| chr12:56,157,307–56,159,499 | 142.1 kb | Distal (>10kb) Multiome | 1008 | |
| chr12:56,188,836–56,190,865 | 110.7 kb | Distal (>10kb) Multiome | 954 | |
| chr12:56,221,094–56,222,691 | 78.4 kb | Distal (>10kb) Multiome | 884 | |
| chr12:56,222,996–56,223,487 | 77.2 kb | Distal (>10kb) Multiome | 38 | |
| chr12:56,223,843–56,224,800 | 76.0 kb | Distal (>10kb) Multiome | 765 | |
| chr12:56,257,471–56,258,774 | 41.9 kb | Distal (>10kb) Multiome | 710 | |
| chr12:56,266,608–56,267,683 | 33.3 kb | Distal (>10kb) Multiome HiCAR | 857 | |
| chr12:56,299,744–56,300,865 | 75 bp | At TSS Multiome HiCAR | 923 | |
| chr12:56,315,380–56,316,674 | 15.8 kb | Distal (>10kb) Multiome HiCAR | 934 | |
| chr12:56,333,366–56,334,588 | 33.6 kb | Distal (>10kb) Multiome HiCAR | 853 | |
| chr12:56,359,808–56,360,881 | 59.9 kb | Distal (>10kb) Multiome | 860 | |
| chr12:56,448,848–56,449,756 | 148.9 kb | Distal (>10kb) Multiome | 920 | |
| chr12:56,468,239–56,468,840 | 168.2 kb | Distal (>10kb) Multiome HiCAR | 907 | |
| chr12:56,487,633–56,488,590 | 188.0 kb | Distal (>10kb) Multiome | 784 |
Genomic view of the CS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.