Transcription factors with Perturb-seq knockdown data for CRYZL2P. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRYZL2P upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRYZL2P, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:178,031,492–178,032,150 | 5.8 kb | Proximal (<10kb) | 297 | |
| chr1:178,033,086–178,033,488 | 4.5 kb | Proximal (<10kb) | 30 | |
| chr1:178,037,496–178,038,215 | at TSS | At TSS | 643 | |
| chr1:178,041,441–178,041,859 | 3.5 kb | Proximal (<10kb) | 6 | |
| chr1:178,042,486–178,043,383 | 4.5 kb | Proximal (<10kb) | 8 |
Genomic view of the CRYZL2P locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.