Transcription factors with Perturb-seq knockdown data for CRTC3-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRTC3-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRTC3-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:90,529,290–90,530,702 | 187.2 kb | Distal (>10kb) Multiome | 627 | |
| chr15:90,708,607–90,708,838 | 8.3 kb | Proximal (<10kb) | 61 | |
| chr15:90,716,853–90,717,827 | 141 bp | At TSS Multiome | 824 | |
| chr15:90,839,491–90,840,162 | 122.6 kb | Distal (>10kb) Multiome | 261 | |
| chr15:90,883,883–90,884,953 | 167.3 kb | Distal (>10kb) Multiome | 304 | |
| chr15:90,902,271–90,903,624 | 185.5 kb | Distal (>10kb) Multiome | 817 | |
| chr15:90,931,729–90,933,077 | 214.8 kb | Distal (>10kb) Multiome | 926 | |
| chr15:90,934,164–90,935,936 | 218.1 kb | Distal (>10kb) Multiome | 701 | |
| chr15:90,954,493–90,955,641 | 237.8 kb | Distal (>10kb) Multiome | 974 | |
| chr15:90,956,070–90,957,754 | 239.6 kb | Distal (>10kb) Multiome | 410 | |
| chr15:90,994,023–90,995,142 | 277.6 kb | Distal (>10kb) Multiome | 929 |
Genomic view of the CRTC3-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.