This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for CRTC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRTC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRTC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:90,233,136–90,234,524 | 295.9 kb | Distal (>10kb) Multiome | 900 | |
| chr15:90,249,345–90,249,851 | 280.4 kb | Distal (>10kb) Multiome | 655 | |
| chr15:90,265,146–90,266,455 | 264.3 kb | Distal (>10kb) Multiome | 956 | |
| chr15:90,293,225–90,293,932 | 236.4 kb | Distal (>10kb) Multiome | 251 | |
| chr15:90,301,063–90,301,545 | 228.6 kb | Distal (>10kb) Multiome | 241 | |
| chr15:90,319,899–90,320,433 | 209.7 kb | Distal (>10kb) Multiome | 503 | |
| chr15:90,351,610–90,352,876 | 177.7 kb | Distal (>10kb) Multiome | 679 | |
| chr15:90,387,660–90,388,880 | 141.8 kb | Distal (>10kb) Multiome | 722 | |
| chr15:90,529,290–90,530,702 | 58 bp | At TSS Multiome | 627 | |
| chr15:90,716,853–90,717,827 | 187.4 kb | Distal (>10kb) Multiome | 824 |
Genomic view of the CRTC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.