CRTC1

CREB regulated transcription coactivator 1 | FLJ14027, KIAA0616, TORC1, MECT1

Enables cAMP response element binding protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-3 Developmental clusters: GC6

Biological processes 19 terms

cAMP response element binding protein binding (GO:0008140)cAMP response element binding protein binding (GO:0008140)cAMP response element binding protein binding (GO:0008140)cellular response to cAMP (GO:0071320)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)entrainment of circadian clock by photoperiod (GO:0043153)entrainment of circadian clock by photoperiod (GO:0043153)nuclear body (GO:0016604)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein homotetramerization (GO:0051289)transcription coactivator activity (GO:0003713)

Expression (TPM)

TFs regulating CRTC1 0 TFs

Transcription factors with Perturb-seq knockdown data for CRTC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRTC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CRTC1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRTC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:18,388,239–18,388,884	295.1 kb	Distal (>10kb) Multiome	910
chr19:18,416,224–18,418,189	267.0 kb	Distal (>10kb) Multiome	893
chr19:18,418,296–18,420,432	264.3 kb	Distal (>10kb) Multiome	773
chr19:18,428,554–18,429,777	254.5 kb	Distal (>10kb) Multiome	489
chr19:18,433,114–18,434,328	249.6 kb	Distal (>10kb) Multiome	446
chr19:18,436,634–18,439,166	246.4 kb	Distal (>10kb) Multiome	799
chr19:18,521,058–18,522,859	161.3 kb	Distal (>10kb) Multiome	849
chr19:18,543,118–18,544,249	140.0 kb	Distal (>10kb) Multiome	574
chr19:18,557,570–18,558,196	125.9 kb	Distal (>10kb) Multiome	738
chr19:18,571,234–18,572,258	112.0 kb	Distal (>10kb) Multiome	972
chr19:18,588,272–18,591,023	93.1 kb	Distal (>10kb) Multiome	1174
chr19:18,593,729–18,595,402	89.2 kb	Distal (>10kb) Multiome	464
chr19:18,611,391–18,612,134	71.9 kb	Distal (>10kb) Multiome	340
chr19:18,635,894–18,637,555	47.0 kb	Distal (>10kb) Multiome	617
chr19:18,682,925–18,684,360	24 bp	At TSS Multiome	701
chr19:18,684,473–18,684,917	796 bp	At TSS	70
chr19:18,785,146–18,785,600	101.7 kb	Distal (>10kb) Multiome	247
chr19:18,831,386–18,833,070	148.2 kb	Distal (>10kb) Multiome	833
chr19:18,870,063–18,870,526	186.8 kb	Distal (>10kb) Multiome	148
chr19:18,895,036–18,896,591	212.5 kb	Distal (>10kb) Multiome	554
chr19:18,918,971–18,919,972	235.9 kb	Distal (>10kb) Multiome	828
chr19:18,932,038–18,933,012	248.9 kb	Distal (>10kb) Multiome	312
chr19:18,940,835–18,941,417	257.6 kb	Distal (>10kb) Multiome	336

Genome Browser

Genomic view of the CRTC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.