The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CRTAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRTAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRTAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:32,815,741–32,817,565 | 297.4 kb | Distal (>10kb) Multiome | 713 | |
| chr3:32,842,816–32,844,607 | 270.4 kb | Distal (>10kb) Multiome | 404 | |
| chr3:32,869,123–32,870,147 | 244.2 kb | Distal (>10kb) Multiome | 264 | |
| chr3:32,902,431–32,903,435 | 210.9 kb | Distal (>10kb) Multiome | 296 | |
| chr3:32,998,701–32,999,462 | 115.0 kb | Distal (>10kb) Multiome | 41 | |
| chr3:33,061,228–33,062,289 | 52.2 kb | Distal (>10kb) Multiome | 238 | |
| chr3:33,096,220–33,097,726 | 16.8 kb | Distal (>10kb) Multiome | 905 | |
| chr3:33,113,579–33,114,881 | 393 bp | At TSS Multiome | 870 | |
| chr3:33,123,029–33,123,482 | 9.0 kb | Proximal (<10kb) | 15 | |
| chr3:33,218,068–33,219,328 | 104.9 kb | Distal (>10kb) Multiome | 329 | |
| chr3:33,277,037–33,277,887 | 163.4 kb | Distal (>10kb) Multiome | 534 |
Genomic view of the CRTAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.