Predicted to enable metal ion binding activity. Predicted to act upstream of or within T cell proliferation. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CRIP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRIP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRIP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:43,013,264–43,014,790 | 294.8 kb | Distal (>10kb) Multiome | 874 | |
| chr6:43,020,970–43,021,878 | 287.4 kb | Distal (>10kb) Multiome | 766 | |
| chr6:43,053,156–43,054,116 | 255.0 kb | Distal (>10kb) Multiome | 1033 | |
| chr6:43,059,118–43,060,383 | 249.2 kb | Distal (>10kb) Multiome | 906 | |
| chr6:43,075,612–43,077,611 | 232.6 kb | Distal (>10kb) Multiome | 744 | |
| chr6:43,143,296–43,143,802 | 165.2 kb | Distal (>10kb) Multiome | 638 | |
| chr6:43,170,289–43,172,815 | 137.6 kb | Distal (>10kb) Multiome | 1025 | |
| chr6:43,173,720–43,174,910 | 134.2 kb | Distal (>10kb) Multiome | 765 | |
| chr6:43,181,838–43,182,555 | 126.6 kb | Distal (>10kb) Multiome | 874 | |
| chr6:43,228,982–43,229,794 | 79.4 kb | Distal (>10kb) Multiome | 918 | |
| chr6:43,246,576–43,247,616 | 61.7 kb | Distal (>10kb) Multiome | 750 | |
| chr6:43,285,054–43,285,508 | 23.5 kb | Distal (>10kb) Multiome | 68 | |
| chr6:43,308,219–43,309,149 | 24 bp | At TSS Multiome | 462 | |
| chr6:43,368,714–43,370,143 | 60.8 kb | Distal (>10kb) Multiome | 909 | |
| chr6:43,426,936–43,428,340 | 118.8 kb | Distal (>10kb) Multiome | 919 | |
| chr6:43,454,362–43,454,991 | 145.9 kb | Distal (>10kb) Multiome | 686 | |
| chr6:43,477,347–43,478,043 | 168.7 kb | Distal (>10kb) Multiome | 747 | |
| chr6:43,509,337–43,511,016 | 201.5 kb | Distal (>10kb) Multiome | 734 | |
| chr6:43,516,463–43,517,515 | 208.2 kb | Distal (>10kb) Multiome | 904 | |
| chr6:43,575,269–43,576,483 | 267.2 kb | Distal (>10kb) Multiome | 1044 |
Genomic view of the CRIP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.