Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CRELD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRELD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRELD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:49,852,925–49,854,755 | 65.0 kb | Distal (>10kb) Multiome | 864 | |
| chr22:49,917,887–49,919,285 | 264 bp | At TSS Multiome | 736 | |
| chr22:49,934,630–49,935,498 | 16.7 kb | Distal (>10kb) Multiome | 298 | |
| chr22:49,935,964–49,936,517 | 17.3 kb | Distal (>10kb) Multiome | 637 | |
| chr22:49,959,889–49,961,612 | 41.7 kb | Distal (>10kb) Multiome | 843 | |
| chr22:49,961,773–49,962,968 | 43.8 kb | Distal (>10kb) Multiome | 708 | |
| chr22:49,999,173–50,000,437 | 80.9 kb | Distal (>10kb) Multiome | 237 | |
| chr22:50,030,288–50,030,739 | 111.7 kb | Distal (>10kb) Multiome | 433 | |
| chr22:50,169,918–50,170,446 | 251.5 kb | Distal (>10kb) Multiome | 245 | |
| chr22:50,184,288–50,186,776 | 267.1 kb | Distal (>10kb) Multiome | 542 | |
| chr22:50,199,706–50,201,679 | 282.2 kb | Distal (>10kb) Multiome | 612 |
Genomic view of the CRELD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.