The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CREG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CREG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CREG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:167,345,001–167,345,700 | 208.3 kb | Distal (>10kb) Multiome | 142 | |
| chr1:167,439,212–167,439,960 | 114.2 kb | Distal (>10kb) Multiome | 362 | |
| chr1:167,454,695–167,456,365 | 98.7 kb | Distal (>10kb) Multiome | 569 | |
| chr1:167,489,386–167,490,223 | 63.9 kb | Distal (>10kb) Multiome | 134 | |
| chr1:167,526,635–167,527,418 | 26.8 kb | Distal (>10kb) Multiome | 77 | |
| chr1:167,533,465–167,534,246 | 19.9 kb | Distal (>10kb) Multiome | 260 | |
| chr1:167,553,117–167,554,407 | 1 bp | At TSS Multiome | 811 | |
| chr1:167,556,019–167,556,393 | 2.3 kb | Proximal (<10kb) | 196 | |
| chr1:167,713,429–167,715,919 | 161.8 kb | Distal (>10kb) Multiome | 1144 | |
| chr1:167,716,321–167,716,922 | 162.8 kb | Distal (>10kb) Multiome | 279 | |
| chr1:167,721,587–167,722,654 | 168.2 kb | Distal (>10kb) Multiome | 729 | |
| chr1:167,735,321–167,736,296 | 182.1 kb | Distal (>10kb) Multiome | 106 | |
| chr1:167,791,182–167,791,821 | 237.8 kb | Distal (>10kb) Multiome | 97 | |
| chr1:167,803,184–167,803,921 | 249.7 kb | Distal (>10kb) Multiome | 643 | |
| chr1:167,819,954–167,820,473 | 266.5 kb | Distal (>10kb) Multiome | 410 | |
| chr1:167,822,319–167,822,995 | 268.9 kb | Distal (>10kb) Multiome | 107 |
Genomic view of the CREG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.