CREB3L2

cAMP responsive element binding protein 3 like 2 | BBF2H7, TCAG_1951439

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Member of: DE-12 Developmental clusters: GC1

Biological processes 28 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)cAMP response element binding (GO:0035497)cAMP response element binding (GO:0035497)cAMP response element binding (GO:0035497)cartilage development (GO:0051216)cartilage development (GO:0051216)chondrocyte differentiation (GO:0002062)chondrocyte differentiation (GO:0002062)chromatin (GO:0000785)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of transcription by RNA polymerase II (GO:0045944)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)response to endoplasmic reticulum stress (GO:0034976)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)

Expression (TPM)

TFs regulating CREB3L2 0 TFs

Transcription factors with Perturb-seq knockdown data for CREB3L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CREB3L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CREB3L2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CREB3L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:137,752,833–137,753,611	248.8 kb	Distal (>10kb) Multiome	70
chr7:137,820,272–137,821,389	181.1 kb	Distal (>10kb) Multiome	228
chr7:137,846,350–137,847,725	155.0 kb	Distal (>10kb) Multiome	330
chr7:137,899,155–137,899,772	102.7 kb	Distal (>10kb) Multiome HiCAR	497
chr7:137,999,974–138,000,690	1.4 kb	Proximal (<10kb)	414
chr7:138,001,408–138,002,587	171 bp	At TSS Multiome	897
chr7:138,008,697–138,009,284	6.7 kb	Proximal (<10kb)	302
chr7:138,014,239–138,015,349	12.7 kb	Distal (>10kb) Multiome	102
chr7:138,161,581–138,162,064	159.7 kb	Distal (>10kb) Multiome	454
chr7:138,167,134–138,168,179	165.6 kb	Distal (>10kb) Multiome	114
chr7:138,168,902–138,169,874	167.5 kb	Distal (>10kb) Multiome	262
chr7:138,207,534–138,207,970	205.7 kb	Distal (>10kb) Multiome	104
chr7:138,249,642–138,250,481	248.0 kb	Distal (>10kb) Multiome HiCAR	87
chr7:138,797,807–138,798,337	796.1 kb	Distal (>10kb) Multiome HiCAR	145

Genome Browser

Genomic view of the CREB3L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.