This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CRCP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRCP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRCP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:65,872,688–65,874,131 | 241.7 kb | Distal (>10kb) Multiome | 352 | |
| chr7:65,981,748–65,982,750 | 132.6 kb | Distal (>10kb) Multiome | 996 | |
| chr7:66,043,712–66,044,711 | 70.5 kb | Distal (>10kb) Multiome | 136 | |
| chr7:66,075,415–66,076,491 | 39.1 kb | Distal (>10kb) Multiome | 802 | |
| chr7:66,099,334–66,100,655 | 14.6 kb | Distal (>10kb) Multiome | 495 | |
| chr7:66,114,557–66,115,604 | 247 bp | At TSS Multiome | 958 | |
| chr7:66,119,448–66,119,670 | 4.6 kb | Proximal (<10kb) | 51 | |
| chr7:66,204,762–66,205,981 | 90.4 kb | Distal (>10kb) Multiome | 816 | |
| chr7:66,413,302–66,414,074 | 298.9 kb | Distal (>10kb) Multiome | 440 |
Genomic view of the CRCP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.