The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for CPVL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPVL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPVL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:28,853,800–28,854,705 | 292.2 kb | Distal (>10kb) Multiome | 539 | |
| chr7:28,955,385–28,958,976 | 189.7 kb | Distal (>10kb) Multiome | 922 | |
| chr7:29,042,753–29,043,889 | 103.3 kb | Distal (>10kb) Multiome | 153 | |
| chr7:29,119,376–29,120,071 | 26.8 kb | Distal (>10kb) Multiome | 66 | |
| chr7:29,128,296–29,129,278 | 17.6 kb | Distal (>10kb) Multiome | 36 | |
| chr7:29,146,054–29,146,726 | 21 bp | At TSS Multiome | 469 | |
| chr7:29,189,638–29,190,162 | 43.4 kb | Distal (>10kb) Multiome | 425 | |
| chr7:29,193,845–29,195,453 | 48.3 kb | Distal (>10kb) Multiome | 618 | |
| chr7:29,197,003–29,197,211 | 1.8 kb | Proximal (<10kb) | 25 |
Genomic view of the CPVL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.