The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CPD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:30,104,595–30,105,065 | 274.1 kb | Distal (>10kb) Multiome | 585 | |
| chr17:30,116,470–30,117,077 | 262.1 kb | Distal (>10kb) Multiome | 800 | |
| chr17:30,291,554–30,292,527 | 86.8 kb | Distal (>10kb) Multiome | 724 | |
| chr17:30,340,166–30,340,693 | 38.4 kb | Distal (>10kb) Multiome | 394 | |
| chr17:30,378,303–30,378,479 | 446 bp | At TSS | 346 | |
| chr17:30,378,665–30,379,625 | 50 bp | At TSS Multiome | 693 | |
| chr17:30,477,182–30,477,726 | 98.4 kb | Distal (>10kb) Multiome | 903 | |
| chr17:30,599,655–30,601,277 | 221.5 kb | Distal (>10kb) Multiome | 793 |
Genomic view of the CPD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.