Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial inner membrane. Implicated in mitochondrial complex IV deficiency nuclear type 22. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COX16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COX16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COX16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:70,143,177–70,143,906 | 273.4 kb | Distal (>10kb) Multiome | 51 | |
| chr14:70,213,776–70,214,482 | 202.9 kb | Distal (>10kb) Multiome | 103 | |
| chr14:70,359,242–70,360,086 | 57.2 kb | Distal (>10kb) Multiome | 1022 | |
| chr14:70,378,111–70,379,006 | 38.4 kb | Distal (>10kb) Multiome | 31 | |
| chr14:70,416,744–70,417,234 | 20 bp | At TSS Multiome | 527 | |
| chr14:70,600,414–70,601,212 | 183.8 kb | Distal (>10kb) Multiome | 519 | |
| chr14:70,641,239–70,642,585 | 224.8 kb | Distal (>10kb) Multiome | 486 | |
| chr14:70,716,516–70,717,866 | 300.1 kb | Distal (>10kb) Multiome | 256 |
Genomic view of the COX16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.