Transcription factors with Perturb-seq knockdown data for COX10-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COX10-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COX10-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:13,600,452–13,602,595 | 467.4 kb | Distal (>10kb) Multiome HiCAR | 570 | |
| chr17:13,922,335–13,923,220 | 146.6 kb | Distal (>10kb) Multiome | 33 | |
| chr17:14,069,121–14,069,983 | 8 bp | At TSS Multiome | 810 | |
| chr17:14,297,092–14,298,113 | 228.1 kb | Distal (>10kb) Multiome | 567 | |
| chr17:14,300,397–14,303,082 | 231.5 kb | Distal (>10kb) Multiome | 904 | |
| chr17:14,308,769–14,310,537 | 240.0 kb | Distal (>10kb) Multiome | 830 | |
| chr17:14,323,613–14,324,323 | 254.4 kb | Distal (>10kb) Multiome | 110 | |
| chr17:14,331,196–14,332,727 | 262.3 kb | Distal (>10kb) Multiome | 319 |
Genomic view of the COX10-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.