Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for CORO1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CORO1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CORO1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:67,239,493–67,240,241 | 203.6 kb | Distal (>10kb) Multiome | 792 | |
| chr11:67,265,898–67,267,077 | 177.1 kb | Distal (>10kb) Multiome | 471 | |
| chr11:67,288,260–67,289,971 | 154.4 kb | Distal (>10kb) Multiome | 985 | |
| chr11:67,302,488–67,304,170 | 140.1 kb | Distal (>10kb) Multiome | 661 | |
| chr11:67,316,992–67,318,501 | 125.8 kb | Distal (>10kb) Multiome | 918 | |
| chr11:67,352,967–67,354,228 | 89.8 kb | Distal (>10kb) Multiome | 781 | |
| chr11:67,372,171–67,373,596 | 70.4 kb | Distal (>10kb) Multiome | 497 | |
| chr11:67,391,276–67,392,428 | 51.6 kb | Distal (>10kb) Multiome | 957 | |
| chr11:67,401,038–67,402,351 | 41.6 kb | Distal (>10kb) Multiome | 741 | |
| chr11:67,420,418–67,421,666 | 22.3 kb | Distal (>10kb) Multiome | 648 | |
| chr11:67,428,036–67,428,950 | 15.1 kb | Distal (>10kb) Multiome | 813 | |
| chr11:67,443,182–67,444,063 | 118 bp | At TSS Multiome | 612 | |
| chr11:67,464,410–67,465,252 | 21.3 kb | Distal (>10kb) Multiome | 710 | |
| chr11:67,468,551–67,469,666 | 25.8 kb | Distal (>10kb) Multiome | 774 | |
| chr11:67,482,830–67,483,745 | 39.7 kb | Distal (>10kb) Multiome | 969 | |
| chr11:67,504,073–67,506,408 | 62.8 kb | Distal (>10kb) Multiome | 769 | |
| chr11:67,507,504–67,509,030 | 64.8 kb | Distal (>10kb) Multiome | 897 | |
| chr11:67,583,474–67,584,777 | 140.2 kb | Distal (>10kb) Multiome | 633 | |
| chr11:67,606,302–67,607,213 | 163.3 kb | Distal (>10kb) Multiome | 781 | |
| chr11:67,614,064–67,614,626 | 170.8 kb | Distal (>10kb) Multiome | 383 | |
| chr11:67,619,429–67,620,391 | 176.3 kb | Distal (>10kb) Multiome | 50 | |
| chr11:67,628,876–67,631,242 | 186.9 kb | Distal (>10kb) Multiome | 1018 |
Genomic view of the CORO1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.