Involved in cellular response to UV; negative regulation of protein neddylation; and positive regulation of cell population proliferation. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COPS9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COPS9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COPS9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:240,024,894–240,026,128 | 110.8 kb | Distal (>10kb) Multiome | 890 | |
| chr2:240,089,041–240,090,019 | 46.8 kb | Distal (>10kb) Multiome | 126 | |
| chr2:240,095,861–240,096,471 | 40.2 kb | Distal (>10kb) Multiome | 110 | |
| chr2:240,135,834–240,136,678 | 64 bp | At TSS Multiome | 753 | |
| chr2:240,143,825–240,144,096 | 7.5 kb | Proximal (<10kb) | 261 | |
| chr2:240,232,596–240,234,436 | 97.1 kb | Distal (>10kb) Multiome | 492 | |
| chr2:240,434,652–240,436,967 | 299.2 kb | Distal (>10kb) Multiome | 516 |
Genomic view of the COPS9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.