Enables histone binding activity. Involved in chromatin remodeling. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COPRS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COPRS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COPRS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:31,391,064–31,392,079 | 467.6 kb | Distal (>10kb) Multiome HiCAR | 148 | |
| chr17:31,487,479–31,489,019 | 371.3 kb | Distal (>10kb) Multiome HiCAR | 681 | |
| chr17:31,489,345–31,490,270 | 369.3 kb | Distal (>10kb) Multiome HiCAR | 362 | |
| chr17:31,549,240–31,550,644 | 309.3 kb | Distal (>10kb) Multiome HiCAR | 945 | |
| chr17:31,558,768–31,559,849 | 300.2 kb | Distal (>10kb) Multiome HiCAR | 630 | |
| chr17:31,842,394–31,842,839 | 16.6 kb | Distal (>10kb) Multiome | 401 | |
| chr17:31,858,598–31,859,915 | 28 bp | At TSS Multiome | 554 | |
| chr17:31,901,289–31,902,051 | 42.6 kb | Distal (>10kb) Multiome | 697 | |
| chr17:31,916,726–31,917,673 | 57.9 kb | Distal (>10kb) Multiome | 134 | |
| chr17:31,936,506–31,937,522 | 77.8 kb | Distal (>10kb) Multiome | 390 | |
| chr17:32,007,010–32,008,197 | 148.2 kb | Distal (>10kb) Multiome | 620 | |
| chr17:32,120,048–32,120,809 | 261.2 kb | Distal (>10kb) Multiome | 65 | |
| chr17:32,127,304–32,127,868 | 268.3 kb | Distal (>10kb) Multiome | 369 | |
| chr17:32,142,020–32,143,266 | 283.2 kb | Distal (>10kb) Multiome | 737 |
Genomic view of the COPRS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.