This gene encodes a protein subunit of the coatomer complex associated with non-clathrin coated vesicles. The coatomer complex, also known as the coat protein complex 1, forms in the cytoplasm and is recruited to the Golgi by activated guanosine triphosphatases. Once at the Golgi membrane, the coatomer complex may assist in the movement of protein and lipid components back to the endoplasmic reticulum. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Transcription factors with Perturb-seq knockdown data for COPB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COPB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COPB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:14,357,756–14,359,493 | 140.8 kb | Distal (>10kb) Multiome | 664 | |
| chr11:14,380,905–14,381,570 | 118.6 kb | Distal (>10kb) Multiome | 501 | |
| chr11:14,499,208–14,500,395 | 23 bp | At TSS Multiome | 813 | |
| chr11:14,500,499–14,500,629 | 637 bp | At TSS | 166 | |
| chr11:14,519,723–14,521,072 | 20.6 kb | Distal (>10kb) Multiome | 1010 | |
| chr11:14,643,085–14,645,138 | 144.0 kb | Distal (>10kb) Multiome | 880 | |
| chr11:14,791,132–14,791,866 | 291.7 kb | Distal (>10kb) Multiome | 119 |
Genomic view of the COPB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.