COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]
Transcription factors with Perturb-seq knockdown data for COMMD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COMMD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COMMD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:75,326,127–75,326,956 | 211.3 kb | Distal (>10kb) Multiome | 339 | |
| chr13:75,480,662–75,482,799 | 55.4 kb | Distal (>10kb) Multiome | 921 | |
| chr13:75,537,361–75,538,569 | 181 bp | At TSS Multiome | 904 | |
| chr13:75,548,880–75,550,494 | 11.7 kb | Distal (>10kb) Multiome | 850 | |
| chr13:75,635,128–75,637,654 | 98.1 kb | Distal (>10kb) Multiome | 863 | |
| chr13:75,802,491–75,803,843 | 265.5 kb | Distal (>10kb) Multiome | 268 |
Genomic view of the COMMD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.