The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for COIL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COIL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COIL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:56,678,153–56,679,472 | 282.1 kb | Distal (>10kb) Multiome | 301 | |
| chr17:56,708,321–56,709,261 | 252.2 kb | Distal (>10kb) Multiome | 92 | |
| chr17:56,779,885–56,780,781 | 180.6 kb | Distal (>10kb) Multiome | 694 | |
| chr17:56,833,054–56,835,255 | 127.1 kb | Distal (>10kb) Multiome | 970 | |
| chr17:56,913,307–56,914,659 | 47.0 kb | Distal (>10kb) Multiome | 1051 | |
| chr17:56,960,529–56,961,254 | 153 bp | At TSS Multiome | 955 | |
| chr17:56,977,708–56,978,393 | 17.0 kb | Distal (>10kb) Multiome | 552 | |
| chr17:57,084,539–57,086,640 | 124.1 kb | Distal (>10kb) Multiome | 1152 | |
| chr17:57,099,741–57,100,357 | 139.0 kb | Distal (>10kb) Multiome | 119 | |
| chr17:57,255,753–57,257,084 | 295.3 kb | Distal (>10kb) Multiome | 661 |
Genomic view of the COIL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.