This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for COG3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COG3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COG3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:45,249,481–45,250,367 | 215.0 kb | Distal (>10kb) Multiome | 120 | |
| chr13:45,310,992–45,312,067 | 153.5 kb | Distal (>10kb) Multiome | 340 | |
| chr13:45,340,420–45,342,118 | 123.5 kb | Distal (>10kb) Multiome | 982 | |
| chr13:45,369,205–45,369,799 | 95.4 kb | Distal (>10kb) Multiome | 26 | |
| chr13:45,370,842–45,371,300 | 93.8 kb | Distal (>10kb) Multiome | 284 | |
| chr13:45,396,133–45,396,998 | 68.2 kb | Distal (>10kb) Multiome | 148 | |
| chr13:45,417,648–45,418,935 | 46.5 kb | Distal (>10kb) Multiome | 793 | |
| chr13:45,464,608–45,465,647 | 67 bp | At TSS Multiome | 854 | |
| chr13:45,737,560–45,738,307 | 272.9 kb | Distal (>10kb) Multiome | 178 |
Genomic view of the COG3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.