The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for COG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:72,592,170–72,593,184 | 600.3 kb | Distal (>10kb) Multiome HiCAR | 837 | |
| chr17:73,092,145–73,093,083 | 100.3 kb | Distal (>10kb) Multiome | 900 | |
| chr17:73,156,070–73,156,871 | 36.7 kb | Distal (>10kb) Multiome | 439 | |
| chr17:73,160,789–73,161,852 | 31.8 kb | Distal (>10kb) Multiome | 148 | |
| chr17:73,164,283–73,166,339 | 28.1 kb | Distal (>10kb) Multiome | 454 | |
| chr17:73,187,206–73,187,665 | 5.4 kb | Proximal (<10kb) | 481 | |
| chr17:73,189,378–73,189,881 | 3.2 kb | Proximal (<10kb) | 355 | |
| chr17:73,191,325–73,191,863 | 1.2 kb | Proximal (<10kb) | 372 | |
| chr17:73,192,033–73,193,741 | 64 bp | At TSS Multiome | 877 | |
| chr17:73,231,620–73,233,239 | 39.4 kb | Distal (>10kb) Multiome | 964 | |
| chr17:73,310,270–73,312,686 | 117.9 kb | Distal (>10kb) Multiome | 1078 | |
| chr17:73,317,321–73,317,925 | 124.5 kb | Distal (>10kb) Multiome | 153 | |
| chr17:73,318,653–73,319,222 | 126.0 kb | Distal (>10kb) Multiome | 44 | |
| chr17:73,341,495–73,342,744 | 149.1 kb | Distal (>10kb) Multiome | 347 | |
| chr17:73,342,845–73,343,860 | 150.4 kb | Distal (>10kb) Multiome | 294 | |
| chr17:73,351,620–73,352,260 | 158.9 kb | Distal (>10kb) Multiome | 17 | |
| chr17:73,359,891–73,361,657 | 168.2 kb | Distal (>10kb) Multiome HiCAR | 310 | |
| chr17:73,363,301–73,364,389 | 170.9 kb | Distal (>10kb) Multiome HiCAR | 140 | |
| chr17:73,492,248–73,493,566 | 299.8 kb | Distal (>10kb) Multiome | 299 |
Genomic view of the COG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.