COA3

cytochrome c oxidase assembly factor 3 | COX25, HSPC009, MITRAC12, hCOA3, CCDC56

This gene encodes a member of the cytochrome c oxidase assembly factor family. Studies of a related gene in fly suggest that the encoded protein is localized to mitochondria and is essential for cytochrome c oxidase function. [provided by RefSeq, Nov 2012]

Member of: DE-1 DE-1.41 Developmental clusters: GC5

Biological processes 13 terms

mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial respiratory chain complex IV assembly (GO:0033617)mitochondrial respiratory chain complex IV assembly (GO:0033617)mitochondrial respiratory chain complex IV assembly (GO:0033617)mitochondrion (GO:0005739)mitochondrion (GO:0005739)positive regulation of mitochondrial translation (GO:0070131)protein binding (GO:0005515)protein folding (GO:0006457)protein folding chaperone (GO:0044183)

Expression (TPM)

TFs regulating COA3 0 TFs

Transcription factors with Perturb-seq knockdown data for COA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to COA3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:42,531,503–42,532,256	266.8 kb	Distal (>10kb) Multiome	571
chr17:42,535,863–42,536,855	262.4 kb	Distal (>10kb) Multiome	987
chr17:42,547,934–42,548,909	250.3 kb	Distal (>10kb) Multiome	325
chr17:42,554,285–42,555,164	243.9 kb	Distal (>10kb) Multiome	899
chr17:42,561,770–42,562,376	236.6 kb	Distal (>10kb) Multiome	905
chr17:42,566,552–42,567,732	231.6 kb	Distal (>10kb) Multiome	902
chr17:42,577,421–42,578,281	220.9 kb	Distal (>10kb) Multiome	884
chr17:42,578,382–42,578,892	220.0 kb	Distal (>10kb) Multiome	477
chr17:42,608,764–42,610,335	189.2 kb	Distal (>10kb) Multiome	909
chr17:42,658,938–42,659,852	139.4 kb	Distal (>10kb) Multiome	734
chr17:42,669,472–42,671,112	128.0 kb	Distal (>10kb) Multiome	230
chr17:42,673,584–42,674,462	124.7 kb	Distal (>10kb) Multiome	296
chr17:42,674,847–42,675,579	123.5 kb	Distal (>10kb) Multiome	194
chr17:42,676,055–42,678,790	121.6 kb	Distal (>10kb) Multiome	1070
chr17:42,679,005–42,680,519	118.8 kb	Distal (>10kb) Multiome	654
chr17:42,682,736–42,683,400	115.9 kb	Distal (>10kb) Multiome	480
chr17:42,744,352–42,745,375	53.8 kb	Distal (>10kb) Multiome	966
chr17:42,761,003–42,761,468	37.7 kb	Distal (>10kb) Multiome	335
chr17:42,780,029–42,780,899	18.2 kb	Distal (>10kb) Multiome	712
chr17:42,798,408–42,798,877	13 bp	At TSS Multiome	866
chr17:42,823,968–42,824,503	25.6 kb	Distal (>10kb) Multiome	829
chr17:42,832,889–42,833,841	34.7 kb	Distal (>10kb) Multiome	980
chr17:42,964,237–42,964,843	165.8 kb	Distal (>10kb) Multiome	655
chr17:42,979,966–42,981,044	181.7 kb	Distal (>10kb) Multiome	843
chr17:42,997,598–42,998,917	199.6 kb	Distal (>10kb) Multiome	1112
chr17:43,021,026–43,022,568	223.7 kb	Distal (>10kb) Multiome	973
chr17:43,024,255–43,025,752	226.3 kb	Distal (>10kb) Multiome	811

Genome Browser

Genomic view of the COA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.