This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]
Transcription factors with Perturb-seq knockdown data for CNOT6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNOT6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNOT6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:180,208,671–180,209,518 | 285.2 kb | Distal (>10kb) Multiome | 385 | |
| chr5:180,291,390–180,292,854 | 202.3 kb | Distal (>10kb) Multiome | 694 | |
| chr5:180,292,972–180,293,953 | 200.7 kb | Distal (>10kb) Multiome | 556 | |
| chr5:180,352,255–180,354,009 | 140.9 kb | Distal (>10kb) Multiome | 450 | |
| chr5:180,493,929–180,495,203 | 40 bp | At TSS Multiome | 803 | |
| chr5:180,618,726–180,619,463 | 124.8 kb | Distal (>10kb) Multiome | 289 | |
| chr5:180,648,868–180,649,861 | 154.8 kb | Distal (>10kb) Multiome | 281 |
Genomic view of the CNOT6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.