Predicted to be involved in mRNA catabolic process and negative regulation of translation. Located in membrane. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CNOT10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNOT10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNOT10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:32,391,537–32,392,862 | 293.3 kb | Distal (>10kb) Multiome | 743 | |
| chr3:32,401,271–32,402,070 | 283.4 kb | Distal (>10kb) Multiome | 697 | |
| chr3:32,410,258–32,411,225 | 274.3 kb | Distal (>10kb) Multiome | 187 | |
| chr3:32,459,983–32,460,759 | 224.9 kb | Distal (>10kb) Multiome | 287 | |
| chr3:32,467,571–32,468,117 | 217.3 kb | Distal (>10kb) Multiome | 389 | |
| chr3:32,502,116–32,503,121 | 182.5 kb | Distal (>10kb) Multiome HiCAR | 723 | |
| chr3:32,569,852–32,571,425 | 114.3 kb | Distal (>10kb) Multiome | 915 | |
| chr3:32,603,070–32,603,802 | 81.8 kb | Distal (>10kb) Multiome | 180 | |
| chr3:32,643,387–32,643,863 | 41.6 kb | Distal (>10kb) Multiome | 118 | |
| chr3:32,684,803–32,685,731 | 21 bp | At TSS Multiome | 954 | |
| chr3:32,780,031–32,781,873 | 95.8 kb | Distal (>10kb) Multiome | 958 | |
| chr3:32,815,741–32,817,565 | 131.4 kb | Distal (>10kb) Multiome | 713 | |
| chr3:32,842,816–32,844,607 | 158.4 kb | Distal (>10kb) Multiome | 404 | |
| chr3:32,869,123–32,870,147 | 184.6 kb | Distal (>10kb) Multiome | 264 | |
| chr3:32,902,431–32,903,435 | 217.9 kb | Distal (>10kb) Multiome | 296 |
Genomic view of the CNOT10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.