This gene encodes a member of the ancient conserved domain protein family. The encoded protein may bind copper. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for CNNM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNNM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNNM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:98,446,188–98,447,219 | 882.5 kb | Distal (>10kb) Multiome HiCAR | 725 | |
| chr10:98,467,326–98,468,343 | 861.7 kb | Distal (>10kb) Multiome HiCAR | 539 | |
| chr10:99,236,018–99,237,092 | 93.1 kb | Distal (>10kb) Multiome | 141 | |
| chr10:99,266,221–99,266,995 | 62.8 kb | Distal (>10kb) Multiome | 113 | |
| chr10:99,321,639–99,322,246 | 7.1 kb | Proximal (<10kb) | 14 | |
| chr10:99,328,995–99,330,768 | at TSS | At TSS | 709 | |
| chr10:99,357,908–99,359,626 | 29.7 kb | Distal (>10kb) Multiome | 160 | |
| chr10:99,370,159–99,370,697 | 41.0 kb | Distal (>10kb) Multiome | 14 | |
| chr10:99,430,207–99,431,536 | 101.5 kb | Distal (>10kb) Multiome | 882 | |
| chr10:99,519,844–99,520,769 | 190.9 kb | Distal (>10kb) Multiome | 331 | |
| chr10:99,522,567–99,524,013 | 193.9 kb | Distal (>10kb) Multiome | 201 | |
| chr10:99,532,575–99,533,287 | 203.5 kb | Distal (>10kb) Multiome | 160 | |
| chr10:99,534,863–99,536,063 | 206.0 kb | Distal (>10kb) Multiome | 193 | |
| chr10:99,536,574–99,538,002 | 207.7 kb | Distal (>10kb) Multiome | 279 | |
| chr10:99,619,825–99,621,725 | 291.4 kb | Distal (>10kb) Multiome | 1070 |
Genomic view of the CNNM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.