The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for CNN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:796,668–798,362 | 229.4 kb | Distal (>10kb) Multiome | 956 | |
| chr19:821,294–822,728 | 204.5 kb | Distal (>10kb) Multiome | 254 | |
| chr19:861,664–863,223 | 164.4 kb | Distal (>10kb) Multiome | 530 | |
| chr19:892,703–893,746 | 133.4 kb | Distal (>10kb) Multiome | 715 | |
| chr19:917,038–918,169 | 108.8 kb | Distal (>10kb) Multiome | 711 | |
| chr19:924,743–926,242 | 100.9 kb | Distal (>10kb) Multiome | 796 | |
| chr19:927,058–927,629 | 99.3 kb | Distal (>10kb) Multiome | 362 | |
| chr19:982,565–983,215 | 43.8 kb | Distal (>10kb) Multiome | 590 | |
| chr19:984,046–985,154 | 42.1 kb | Distal (>10kb) Multiome | 829 | |
| chr19:1,000,142–1,000,881 | 26.3 kb | Distal (>10kb) Multiome | 399 | |
| chr19:1,020,611–1,022,069 | 5.2 kb | Proximal (<10kb) Multiome | 1017 | |
| chr19:1,026,155–1,026,856 | 119 bp | At TSS Multiome | 598 | |
| chr19:1,027,770–1,028,926 | 1.9 kb | Proximal (<10kb) Multiome | 584 | |
| chr19:1,030,704–1,030,919 | 4.1 kb | Proximal (<10kb) | 168 | |
| chr19:1,039,648–1,040,400 | 13.4 kb | Distal (>10kb) Multiome | 684 | |
| chr19:1,040,481–1,041,402 | 14.6 kb | Distal (>10kb) Multiome | 556 | |
| chr19:1,044,758–1,045,598 | 18.7 kb | Distal (>10kb) Multiome | 402 | |
| chr19:1,061,840–1,062,923 | 35.9 kb | Distal (>10kb) Multiome | 204 | |
| chr19:1,063,045–1,065,722 | 38.2 kb | Distal (>10kb) Multiome | 681 | |
| chr19:1,066,682–1,067,587 | 40.6 kb | Distal (>10kb) Multiome | 489 | |
| chr19:1,071,107–1,071,721 | 44.5 kb | Distal (>10kb) Multiome | 178 | |
| chr19:1,081,317–1,083,172 | 55.8 kb | Distal (>10kb) Multiome | 484 | |
| chr19:1,094,985–1,095,654 | 68.8 kb | Distal (>10kb) Multiome | 671 | |
| chr19:1,103,487–1,105,654 | 77.4 kb | Distal (>10kb) Multiome | 849 | |
| chr19:1,112,029–1,112,884 | 85.7 kb | Distal (>10kb) Multiome | 294 | |
| chr19:1,113,014–1,114,139 | 86.9 kb | Distal (>10kb) Multiome | 690 | |
| chr19:1,122,934–1,123,720 | 96.6 kb | Distal (>10kb) Multiome | 231 | |
| chr19:1,173,441–1,174,438 | 147.6 kb | Distal (>10kb) Multiome | 682 | |
| chr19:1,194,370–1,194,985 | 168.0 kb | Distal (>10kb) Multiome | 531 | |
| chr19:1,205,175–1,206,374 | 179.0 kb | Distal (>10kb) Multiome HiCAR | 746 | |
| chr19:1,237,080–1,238,434 | 211.5 kb | Distal (>10kb) Multiome | 430 | |
| chr19:1,239,513–1,242,539 | 215.1 kb | Distal (>10kb) Multiome | 889 | |
| chr19:1,244,253–1,244,857 | 218.0 kb | Distal (>10kb) Multiome | 590 | |
| chr19:1,247,981–1,252,501 | 224.4 kb | Distal (>10kb) Multiome | 1136 | |
| chr19:1,259,185–1,262,955 | 232.8 kb | Distal (>10kb) Multiome | 1070 | |
| chr19:1,265,280–1,270,235 | 242.7 kb | Distal (>10kb) Multiome | 1171 | |
| chr19:1,274,423–1,276,502 | 249.1 kb | Distal (>10kb) Multiome | 967 | |
| chr19:1,285,317–1,286,108 | 259.2 kb | Distal (>10kb) Multiome | 277 |
Genomic view of the CNN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.