Predicted to enable actin filament binding activity. Involved in negative regulation of vascular associated smooth muscle cell proliferation. Located in cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CNN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:11,243,345–11,243,968 | 295.3 kb | Distal (>10kb) Multiome | 448 | |
| chr19:11,262,060–11,262,653 | 276.4 kb | Distal (>10kb) Multiome | 406 | |
| chr19:11,339,100–11,339,837 | 199.2 kb | Distal (>10kb) Multiome | 506 | |
| chr19:11,346,053–11,346,958 | 192.4 kb | Distal (>10kb) Multiome | 676 | |
| chr19:11,355,078–11,355,735 | 183.4 kb | Distal (>10kb) Multiome | 382 | |
| chr19:11,361,368–11,362,625 | 177.2 kb | Distal (>10kb) Multiome | 256 | |
| chr19:11,374,474–11,375,717 | 163.9 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,380,761–11,382,262 | 157.5 kb | Distal (>10kb) Multiome | 798 | |
| chr19:11,382,830–11,384,509 | 154.5 kb | Distal (>10kb) Multiome | 761 | |
| chr19:11,418,061–11,419,498 | 120.2 kb | Distal (>10kb) Multiome | 421 | |
| chr19:11,420,614–11,422,979 | 116.7 kb | Distal (>10kb) Multiome | 507 | |
| chr19:11,434,817–11,436,365 | 103.5 kb | Distal (>10kb) Multiome | 927 | |
| chr19:11,479,217–11,480,146 | 59.2 kb | Distal (>10kb) Multiome | 394 | |
| chr19:11,481,847–11,483,040 | 56.6 kb | Distal (>10kb) Multiome | 938 | |
| chr19:11,504,741–11,506,612 | 33.5 kb | Distal (>10kb) Multiome | 854 | |
| chr19:11,528,581–11,529,391 | 9.7 kb | Proximal (<10kb) Multiome | 866 | |
| chr19:11,530,487–11,530,757 | 8.1 kb | Proximal (<10kb) | 378 | |
| chr19:11,535,847–11,536,353 | 2.7 kb | Proximal (<10kb) Multiome | 694 | |
| chr19:11,538,464–11,539,111 | 95 bp | At TSS Multiome | 235 | |
| chr19:11,539,738–11,540,434 | 1.2 kb | Proximal (<10kb) Multiome | 176 | |
| chr19:11,558,908–11,559,777 | 20.4 kb | Distal (>10kb) Multiome | 686 | |
| chr19:11,597,206–11,598,107 | 58.6 kb | Distal (>10kb) Multiome | 914 | |
| chr19:11,639,337–11,640,481 | 100.9 kb | Distal (>10kb) Multiome | 660 | |
| chr19:11,694,497–11,695,341 | 156.2 kb | Distal (>10kb) Multiome | 608 | |
| chr19:11,737,998–11,739,422 | 200.1 kb | Distal (>10kb) Multiome | 704 |
Genomic view of the CNN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.