Enables CCR5 chemokine receptor binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CNIH4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNIH4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNIH4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:224,113,911–224,114,795 | 242.7 kb | Distal (>10kb) Multiome | 853 | |
| chr1:224,182,841–224,184,249 | 173.6 kb | Distal (>10kb) Multiome | 901 | |
| chr1:224,329,851–224,330,705 | 26.6 kb | Distal (>10kb) Multiome | 865 | |
| chr1:224,356,549–224,357,612 | 71 bp | At TSS Multiome | 791 | |
| chr1:224,434,594–224,435,312 | 78.0 kb | Distal (>10kb) Multiome | 865 | |
| chr1:224,498,011–224,499,031 | 141.8 kb | Distal (>10kb) Multiome | 326 | |
| chr1:224,502,820–224,504,228 | 146.7 kb | Distal (>10kb) Multiome | 820 | |
| chr1:224,615,699–224,617,266 | 259.3 kb | Distal (>10kb) Multiome | 511 | |
| chr1:224,639,152–224,640,098 | 282.7 kb | Distal (>10kb) Multiome | 68 |
Genomic view of the CNIH4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.