CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for CNDP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNDP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNDP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:72,692,057–72,692,906 | 1803.9 kb | Distal (>10kb) Multiome HiCAR | 173 | |
| chr18:74,281,103–74,282,795 | 213.7 kb | Distal (>10kb) Multiome HiCAR | 450 | |
| chr18:74,290,874–74,292,549 | 204.3 kb | Distal (>10kb) Multiome | 848 | |
| chr18:74,493,711–74,494,105 | 2.3 kb | Proximal (<10kb) | 85 | |
| chr18:74,495,189–74,495,319 | 1.0 kb | Proximal (<10kb) | 14 | |
| chr18:74,495,562–74,497,259 | 144 bp | At TSS Multiome | 913 | |
| chr18:74,499,747–74,499,960 | 3.4 kb | Proximal (<10kb) | 244 | |
| chr18:74,505,496–74,506,014 | 9.1 kb | Proximal (<10kb) | 20 | |
| chr18:74,507,531–74,509,605 | 12.6 kb | Distal (>10kb) Multiome | 369 | |
| chr18:74,562,032–74,563,296 | 66.1 kb | Distal (>10kb) Multiome | 144 | |
| chr18:74,597,119–74,599,116 | 101.6 kb | Distal (>10kb) Multiome | 919 |
Genomic view of the CNDP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.