Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CMTR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CMTR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CMTR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:37,137,028–37,138,409 | 295.5 kb | Distal (>10kb) Multiome | 735 | |
| chr6:37,141,368–37,141,988 | 291.5 kb | Distal (>10kb) Multiome | 239 | |
| chr6:37,168,853–37,171,673 | 263.3 kb | Distal (>10kb) Multiome | 1096 | |
| chr6:37,172,048–37,172,496 | 260.9 kb | Distal (>10kb) Multiome | 818 | |
| chr6:37,221,712–37,222,953 | 210.6 kb | Distal (>10kb) Multiome | 747 | |
| chr6:37,257,338–37,258,482 | 175.4 kb | Distal (>10kb) Multiome | 890 | |
| chr6:37,319,150–37,319,973 | 113.6 kb | Distal (>10kb) Multiome | 54 | |
| chr6:37,353,783–37,354,458 | 79.2 kb | Distal (>10kb) Multiome | 794 | |
| chr6:37,432,813–37,433,740 | 16 bp | At TSS Multiome | 901 | |
| chr6:37,484,079–37,484,645 | 51.1 kb | Distal (>10kb) Multiome | 222 | |
| chr6:37,499,465–37,500,524 | 66.7 kb | Distal (>10kb) Multiome | 714 | |
| chr6:37,565,348–37,566,769 | 132.6 kb | Distal (>10kb) Multiome | 518 | |
| chr6:37,647,989–37,649,458 | 215.6 kb | Distal (>10kb) Multiome | 333 | |
| chr6:37,697,011–37,698,118 | 264.6 kb | Distal (>10kb) Multiome | 456 | |
| chr6:37,705,006–37,706,173 | 272.4 kb | Distal (>10kb) Multiome | 470 |
Genomic view of the CMTR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.