This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for CMTM7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CMTM7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CMTM7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:32,105,961–32,107,302 | 285.4 kb | Distal (>10kb) Multiome | 774 | |
| chr3:32,237,938–32,239,504 | 153.2 kb | Distal (>10kb) Multiome | 757 | |
| chr3:32,391,537–32,392,862 | 26 bp | At TSS Multiome | 743 | |
| chr3:32,401,271–32,402,070 | 9.9 kb | Proximal (<10kb) Multiome | 697 | |
| chr3:32,410,258–32,411,225 | 19.0 kb | Distal (>10kb) Multiome | 187 | |
| chr3:32,459,983–32,460,759 | 68.4 kb | Distal (>10kb) Multiome HiCAR | 287 | |
| chr3:32,467,571–32,468,117 | 76.0 kb | Distal (>10kb) Multiome HiCAR | 389 | |
| chr3:32,502,116–32,503,121 | 110.8 kb | Distal (>10kb) Multiome | 723 | |
| chr3:32,569,852–32,571,425 | 179.0 kb | Distal (>10kb) Multiome | 915 | |
| chr3:32,603,070–32,603,802 | 211.5 kb | Distal (>10kb) Multiome | 180 | |
| chr3:32,643,387–32,643,863 | 251.7 kb | Distal (>10kb) Multiome | 118 | |
| chr3:32,684,803–32,685,731 | 293.3 kb | Distal (>10kb) Multiome | 954 |
Genomic view of the CMTM7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.