Predicted to enable metal ion binding activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CMC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CMC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CMC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:27,632,489–27,633,437 | 608.6 kb | Distal (>10kb) Multiome HiCAR | 378 | |
| chr3:27,711,660–27,716,254 | 527.5 kb | Distal (>10kb) Multiome HiCAR | 783 | |
| chr3:27,720,744–27,724,896 | 518.8 kb | Distal (>10kb) Multiome HiCAR | 708 | |
| chr3:27,727,875–27,731,045 | 511.2 kb | Distal (>10kb) Multiome HiCAR | 446 | |
| chr3:28,239,215–28,239,408 | 2.2 kb | Proximal (<10kb) | 35 | |
| chr3:28,240,444–28,242,372 | 2 bp | At TSS Multiome | 1004 | |
| chr3:28,348,014–28,349,873 | 107.4 kb | Distal (>10kb) Multiome | 1118 |
Genomic view of the CMC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.