This gene encodes an enzyme that converts N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc). This process is important in the formation of sialylated glycoprotein and glycolipids. This modification plays a role in cell-cell communications and immune responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for CMAS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CMAS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CMAS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:21,774,351–21,775,580 | 271.4 kb | Distal (>10kb) Multiome | 443 | |
| chr12:21,971,066–21,971,938 | 74.8 kb | Distal (>10kb) Multiome | 150 | |
| chr12:22,040,341–22,041,417 | 4.9 kb | Proximal (<10kb) | 17 | |
| chr12:22,043,841–22,044,622 | 1.7 kb | Proximal (<10kb) | 52 | |
| chr12:22,045,900–22,047,085 | 115 bp | At TSS Multiome | 738 | |
| chr12:22,048,329–22,048,977 | 2.0 kb | Proximal (<10kb) | 167 | |
| chr12:22,245,670–22,246,345 | 199.8 kb | Distal (>10kb) Multiome | 45 | |
| chr12:22,333,730–22,336,157 | 289.3 kb | Distal (>10kb) Multiome | 600 | |
| chr12:22,436,588–22,437,692 | 391.0 kb | Distal (>10kb) Multiome HiCAR | 80 | |
| chr12:22,443,250–22,443,763 | 397.3 kb | Distal (>10kb) Multiome HiCAR | 286 |
Genomic view of the CMAS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.