Enables mRNA binding activity. Involved in intracellular distribution of mitochondria and mitochondrion organization. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CLUH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLUH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLUH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:2,511,517–2,512,317 | 199.9 kb | Distal (>10kb) Multiome | 698 | |
| chr17:2,592,971–2,594,792 | 118.2 kb | Distal (>10kb) Multiome | 853 | |
| chr17:2,691,692–2,692,319 | 19.8 kb | Distal (>10kb) Multiome | 66 | |
| chr17:2,707,740–2,707,931 | 3.9 kb | Proximal (<10kb) | 149 | |
| chr17:2,710,909–2,712,254 | 30 bp | At TSS Multiome | 864 | |
| chr17:2,716,507–2,717,103 | 4.7 kb | Proximal (<10kb) | 112 | |
| chr17:2,723,482–2,725,106 | 12.3 kb | Distal (>10kb) Multiome | 477 | |
| chr17:2,749,134–2,750,125 | 38.1 kb | Distal (>10kb) Multiome | 859 | |
| chr17:2,755,248–2,756,668 | 43.7 kb | Distal (>10kb) Multiome | 347 | |
| chr17:2,776,093–2,777,278 | 65.0 kb | Distal (>10kb) Multiome | 372 | |
| chr17:2,786,083–2,786,614 | 74.6 kb | Distal (>10kb) Multiome | 526 | |
| chr17:2,852,945–2,854,316 | 141.8 kb | Distal (>10kb) Multiome | 362 | |
| chr17:2,874,180–2,874,725 | 162.6 kb | Distal (>10kb) Multiome | 101 |
Genomic view of the CLUH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.