This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Transcription factors with Perturb-seq knockdown data for CLTCL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLTCL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLTCL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:19,116,923–19,117,513 | 174.6 kb | Distal (>10kb) Multiome | 54 | |
| chr22:19,121,544–19,123,310 | 169.2 kb | Distal (>10kb) Multiome | 690 | |
| chr22:19,144,380–19,144,950 | 147.0 kb | Distal (>10kb) Multiome | 696 | |
| chr22:19,149,463–19,150,252 | 142.1 kb | Distal (>10kb) Multiome | 173 | |
| chr22:19,169,265–19,169,982 | 122.0 kb | Distal (>10kb) Multiome | 285 | |
| chr22:19,170,964–19,172,196 | 120.1 kb | Distal (>10kb) Multiome | 819 | |
| chr22:19,177,562–19,180,087 | 112.9 kb | Distal (>10kb) Multiome | 875 | |
| chr22:19,290,875–19,292,389 | 64 bp | At TSS Multiome | 854 | |
| chr22:19,431,488–19,432,799 | 140.6 kb | Distal (>10kb) Multiome | 1140 | |
| chr22:19,446,962–19,448,379 | 155.9 kb | Distal (>10kb) Multiome | 889 | |
| chr22:19,478,898–19,480,311 | 188.0 kb | Distal (>10kb) Multiome | 867 | |
| chr22:19,523,289–19,524,793 | 231.9 kb | Distal (>10kb) Multiome | 242 |
Genomic view of the CLTCL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.