Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CLTC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLTC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLTC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:59,329,140–59,330,952 | 290.1 kb | Distal (>10kb) Multiome | 623 | |
| chr17:59,331,110–59,332,553 | 288.3 kb | Distal (>10kb) Multiome | 723 | |
| chr17:59,365,177–59,365,986 | 254.2 kb | Distal (>10kb) Multiome | 397 | |
| chr17:59,366,194–59,368,736 | 252.9 kb | Distal (>10kb) Multiome | 784 | |
| chr17:59,370,634–59,371,353 | 249.0 kb | Distal (>10kb) Multiome | 95 | |
| chr17:59,418,775–59,419,543 | 200.8 kb | Distal (>10kb) Multiome | 216 | |
| chr17:59,423,282–59,424,320 | 195.9 kb | Distal (>10kb) Multiome | 316 | |
| chr17:59,565,384–59,566,262 | 54.2 kb | Distal (>10kb) Multiome | 1120 | |
| chr17:59,619,053–59,620,313 | 215 bp | At TSS Multiome | 1183 | |
| chr17:59,620,529–59,620,814 | 846 bp | At TSS | 170 | |
| chr17:59,620,998–59,621,238 | 1.3 kb | Proximal (<10kb) | 230 | |
| chr17:59,707,078–59,708,143 | 87.7 kb | Distal (>10kb) Multiome | 963 | |
| chr17:59,837,406–59,838,036 | 217.9 kb | Distal (>10kb) Multiome | 865 | |
| chr17:59,892,295–59,893,854 | 273.2 kb | Distal (>10kb) Multiome | 992 |
Genomic view of the CLTC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.