Predicted to enable GABA receptor binding activity. Predicted to be involved in regulation of T cell differentiation in thymus. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CLPTM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLPTM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLPTM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:44,747,085–44,747,789 | 207.8 kb | Distal (>10kb) Multiome | 653 | |
| chr19:44,757,112–44,758,480 | 198.0 kb | Distal (>10kb) Multiome | 209 | |
| chr19:44,758,633–44,759,104 | 196.5 kb | Distal (>10kb) Multiome | 80 | |
| chr19:44,770,589–44,771,108 | 184.6 kb | Distal (>10kb) Multiome | 367 | |
| chr19:44,777,671–44,778,314 | 177.5 kb | Distal (>10kb) Multiome | 353 | |
| chr19:44,800,231–44,800,829 | 154.7 kb | Distal (>10kb) Multiome | 508 | |
| chr19:44,807,965–44,809,338 | 147.3 kb | Distal (>10kb) Multiome | 652 | |
| chr19:44,844,448–44,848,668 | 110.6 kb | Distal (>10kb) Multiome | 1047 | |
| chr19:44,890,209–44,891,796 | 64.5 kb | Distal (>10kb) Multiome | 952 | |
| chr19:44,903,686–44,904,241 | 51.6 kb | Distal (>10kb) Multiome HiCAR | 666 | |
| chr19:44,905,114–44,907,037 | 48.7 kb | Distal (>10kb) Multiome HiCAR | 645 | |
| chr19:44,913,546–44,915,671 | 40.2 kb | Distal (>10kb) Multiome HiCAR | 587 | |
| chr19:44,926,693–44,927,388 | 28.2 kb | Distal (>10kb) Multiome | 277 | |
| chr19:44,951,464–44,951,832 | 3.5 kb | Proximal (<10kb) | 250 | |
| chr19:44,954,641–44,955,824 | 135 bp | At TSS Multiome | 835 | |
| chr19:45,001,031–45,002,639 | 46.0 kb | Distal (>10kb) Multiome | 694 | |
| chr19:45,038,879–45,039,566 | 83.8 kb | Distal (>10kb) Multiome | 800 | |
| chr19:45,075,125–45,076,814 | 121.1 kb | Distal (>10kb) Multiome | 710 | |
| chr19:45,078,897–45,080,647 | 124.8 kb | Distal (>10kb) Multiome | 1012 | |
| chr19:45,091,042–45,093,574 | 137.6 kb | Distal (>10kb) Multiome | 959 | |
| chr19:45,177,803–45,179,711 | 223.1 kb | Distal (>10kb) Multiome | 899 | |
| chr19:45,234,200–45,234,822 | 279.2 kb | Distal (>10kb) Multiome | 105 | |
| chr19:45,250,821–45,251,491 | 295.8 kb | Distal (>10kb) Multiome | 397 |
Genomic view of the CLPTM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.