This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for CLIC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLIC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLIC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:34,614,583–34,615,668 | 53.7 kb | Distal (>10kb) Multiome | 722 | |
| chr21:34,668,856–34,669,852 | at TSS | At TSS | 156 | |
| chr21:34,745,569–34,746,197 | 76.7 kb | Distal (>10kb) Multiome | 505 | |
| chr21:34,888,547–34,890,899 | 221.2 kb | Distal (>10kb) Multiome | 896 | |
| chr21:35,525,807–35,526,243 | 857.0 kb | Distal (>10kb) Multiome HiCAR | 59 | |
| chr21:36,059,813–36,061,105 | 1391.5 kb | Distal (>10kb) Multiome HiCAR | 865 | |
| chr21:36,069,719–36,070,524 | 1401.0 kb | Distal (>10kb) Multiome HiCAR | 634 |
Genomic view of the CLIC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.