This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for CLEC16A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLEC16A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLEC16A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:10,743,473–10,744,692 | 200.4 kb | Distal (>10kb) Multiome | 1045 | |
| chr16:10,818,333–10,818,889 | 126.0 kb | Distal (>10kb) Multiome | 127 | |
| chr16:10,942,009–10,942,939 | 2.1 kb | Proximal (<10kb) Multiome | 627 | |
| chr16:10,944,257–10,944,954 | 92 bp | At TSS Multiome | 887 | |
| chr16:10,949,449–10,949,898 | 4.9 kb | Proximal (<10kb) | 184 | |
| chr16:10,954,029–10,954,204 | 9.4 kb | Proximal (<10kb) | 246 | |
| chr16:11,032,660–11,033,355 | 88.5 kb | Distal (>10kb) Multiome | 81 | |
| chr16:11,104,839–11,105,431 | 160.5 kb | Distal (>10kb) Multiome | 471 | |
| chr16:11,254,519–11,257,585 | 311.5 kb | Distal (>10kb) Multiome HiCAR | 1111 |
Genomic view of the CLEC16A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.