This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]
Transcription factors with Perturb-seq knockdown data for CKAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CKAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CKAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:52,159,155–52,160,117 | 295.9 kb | Distal (>10kb) Multiome HiCAR | 831 | |
| chr13:52,194,155–52,194,839 | 261.0 kb | Distal (>10kb) Multiome HiCAR | 888 | |
| chr13:52,195,279–52,195,948 | 259.8 kb | Distal (>10kb) Multiome | 267 | |
| chr13:52,449,904–52,451,090 | 4.8 kb | Proximal (<10kb) Multiome | 972 | |
| chr13:52,454,948–52,456,258 | 10 bp | At TSS Multiome | 791 | |
| chr13:52,599,686–52,600,643 | 144.8 kb | Distal (>10kb) Multiome | 545 | |
| chr13:52,617,038–52,617,928 | 161.9 kb | Distal (>10kb) Multiome | 723 | |
| chr13:52,651,967–52,653,338 | 197.2 kb | Distal (>10kb) Multiome | 966 | |
| chr13:52,738,655–52,740,130 | 283.6 kb | Distal (>10kb) Multiome | 284 |
Genomic view of the CKAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.