CIART

circadian associated repressor of transcription | BC017397, CHRONO, C1orf51

Predicted to enable E-box binding activity. Predicted to be involved in circadian regulation of gene expression; locomotor rhythm; and negative regulation of DNA-templated transcription. Predicted to be located in PML body. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC2

Biological processes 18 terms

E-box binding (GO:0070888)E-box binding (GO:0070888)PML body (GO:0016605)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)circadian regulation of gene expression (GO:0032922)circadian regulation of gene expression (GO:0032922)circadian regulation of gene expression (GO:0032922)locomotor rhythm (GO:0045475)locomotor rhythm (GO:0045475)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)transcription cis-regulatory region binding (GO:0000976)

Expression (TPM)

TFs regulating CIART 0 TFs

Transcription factors with Perturb-seq knockdown data for CIART. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CIART upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CIART

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CIART, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:150,010,143–150,011,088	271.8 kb	Distal (>10kb) Multiome	961
chr1:150,066,903–150,067,886	214.9 kb	Distal (>10kb) Multiome	986
chr1:150,149,493–150,150,439	132.5 kb	Distal (>10kb) Multiome	448
chr1:150,162,838–150,163,636	119.3 kb	Distal (>10kb) Multiome	550
chr1:150,213,532–150,214,095	68.8 kb	Distal (>10kb) Multiome	441
chr1:150,234,435–150,235,519	47.8 kb	Distal (>10kb) Multiome	725
chr1:150,235,635–150,236,696	46.3 kb	Distal (>10kb) Multiome	905
chr1:150,255,443–150,256,199	26.8 kb	Distal (>10kb) Multiome	441
chr1:150,256,563–150,257,324	25.5 kb	Distal (>10kb) Multiome	223
chr1:150,257,589–150,258,594	24.4 kb	Distal (>10kb) Multiome	233
chr1:150,259,728–150,260,778	22.4 kb	Distal (>10kb) Multiome	362
chr1:150,268,574–150,269,453	13.4 kb	Distal (>10kb) Multiome	785
chr1:150,272,599–150,272,771	9.8 kb	Proximal (<10kb)	122
chr1:150,281,356–150,281,530	1.0 kb	Proximal (<10kb)	155
chr1:150,281,629–150,283,038	113 bp	At TSS Multiome	503
chr1:150,293,680–150,294,144	11.3 kb	Distal (>10kb) Multiome	755
chr1:150,313,761–150,314,506	31.5 kb	Distal (>10kb) Multiome	108
chr1:150,321,137–150,321,825	39.0 kb	Distal (>10kb) Multiome	806
chr1:150,363,368–150,364,980	81.5 kb	Distal (>10kb) Multiome	971
chr1:150,487,154–150,487,710	204.8 kb	Distal (>10kb) Multiome	929
chr1:150,515,085–150,516,227	233.1 kb	Distal (>10kb) Multiome	781
chr1:150,548,849–150,549,823	266.7 kb	Distal (>10kb) Multiome	620
chr1:150,560,828–150,562,623	278.8 kb	Distal (>10kb) Multiome	897
chr1:150,578,554–150,580,300	297.1 kb	Distal (>10kb) Multiome	990

Genome Browser

Genomic view of the CIART locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.