Predicted to enable zinc ion binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CHURC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHURC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHURC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:64,645,238–64,645,989 | 268.8 kb | Distal (>10kb) Multiome | 252 | |
| chr14:64,657,975–64,659,082 | 255.8 kb | Distal (>10kb) Multiome | 104 | |
| chr14:64,688,830–64,689,973 | 225.3 kb | Distal (>10kb) Multiome | 173 | |
| chr14:64,702,676–64,705,752 | 210.0 kb | Distal (>10kb) Multiome | 771 | |
| chr14:64,708,103–64,708,910 | 206.0 kb | Distal (>10kb) Multiome | 355 | |
| chr14:64,764,629–64,765,271 | 149.5 kb | Distal (>10kb) Multiome | 313 | |
| chr14:64,823,107–64,823,713 | 91.0 kb | Distal (>10kb) Multiome HiCAR | 316 | |
| chr14:64,879,129–64,880,883 | 34.0 kb | Distal (>10kb) Multiome | 485 | |
| chr14:64,914,197–64,914,885 | 4 bp | At TSS Multiome | 741 | |
| chr14:64,971,572–64,972,862 | 57.9 kb | Distal (>10kb) Multiome | 360 | |
| chr14:64,986,666–64,987,558 | 72.6 kb | Distal (>10kb) Multiome | 890 | |
| chr14:65,079,469–65,080,344 | 165.5 kb | Distal (>10kb) Multiome | 80 | |
| chr14:65,101,709–65,103,353 | 188.2 kb | Distal (>10kb) Multiome | 804 | |
| chr14:65,187,313–65,188,086 | 273.2 kb | Distal (>10kb) Multiome | 124 | |
| chr14:65,212,664–65,213,594 | 298.8 kb | Distal (>10kb) Multiome | 50 |
Genomic view of the CHURC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.