CHTF18
chromosome transmission fidelity factor 18 | C321D2.4, CHL12, Ctf18, C16orf41

This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016]

Member of: DE-11 Developmental clusters: GC2
Biological processes 19 terms
ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)Ctf18 RFC-like complex (GO:0031390)DNA binding (GO:0003677)DNA clamp loader activity (GO:0003689)DNA clamp loader activity (GO:0003689)DNA replication (GO:0006260)chromosome (GO:0005694)cytoplasm (GO:0005737)membrane (GO:0016020)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-directed DNA polymerase activity (GO:1900264)protein binding (GO:0005515)single-stranded DNA helicase activity (GO:0017116)single-stranded DNA helicase activity (GO:0017116)
Expression (TPM)
CHTF18 — as a Regulated Gene

TFs regulating CHTF18 0 TFs

Transcription factors with Perturb-seq knockdown data for CHTF18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHTF18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CHTF18

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHTF18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:526,749–528,601 261.0 kb Distal (>10kb) Multiome 811
chr16:569,530–570,338 218.8 kb Distal (>10kb) Multiome 492
chr16:578,896–579,353 209.5 kb Distal (>10kb) Multiome 511
chr16:588,593–590,724 198.7 kb Distal (>10kb) Multiome 853
chr16:635,900–638,127 152.3 kb Distal (>10kb) Multiome 1021
chr16:641,491–643,007 146.8 kb Distal (>10kb) Multiome 856
chr16:648,795–649,829 139.3 kb Distal (>10kb) Multiome 862
chr16:660,457–661,656 127.7 kb Distal (>10kb) Multiome 456
chr16:667,633–668,442 120.6 kb Distal (>10kb) Multiome 838
chr16:678,847–681,585 108.6 kb Distal (>10kb) Multiome 803
chr16:683,618–684,859 104.2 kb Distal (>10kb) Multiome 701
chr16:694,897–695,485 93.2 kb Distal (>10kb) Multiome 390
chr16:705,242–706,468 82.7 kb Distal (>10kb) Multiome 248
chr16:714,577–716,048 73.5 kb Distal (>10kb) Multiome HiCAR 555
chr16:720,434–721,963 67.3 kb Distal (>10kb) Multiome HiCAR 966
chr16:726,310–729,144 61.6 kb Distal (>10kb) Multiome HiCAR 736
chr16:740,359–741,596 47.5 kb Distal (>10kb) Multiome HiCAR 897
chr16:785,466–785,876 2.7 kb Proximal (<10kb) 320
chr16:787,564–789,160 121 bp At TSS Multiome 635
chr16:807,352–808,044 19.2 kb Distal (>10kb) Multiome 600
chr16:813,330–813,960 25.2 kb Distal (>10kb) Multiome 325
chr16:970,016–971,733 182.4 kb Distal (>10kb) Multiome 800
chr16:980,014–982,920 192.8 kb Distal (>10kb) Multiome 499
chr16:1,048,353–1,048,991 260.0 kb Distal (>10kb) Multiome 220
chr16:1,088,257–1,088,904 300.0 kb Distal (>10kb) Multiome 201
chr16:1,102,896–1,103,532 314.6 kb Distal (>10kb) Multiome HiCAR 331

Genome Browser

Genomic view of the CHTF18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:516,749 – 1,113,532
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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