The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for CHST11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHST11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHST11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:104,215,473–104,216,381 | 241.1 kb | Distal (>10kb) Multiome | 514 | |
| chr12:104,286,560–104,287,505 | 170.0 kb | Distal (>10kb) Multiome | 878 | |
| chr12:104,288,643–104,289,175 | 168.1 kb | Distal (>10kb) Multiome | 863 | |
| chr12:104,303,321–104,304,194 | 153.2 kb | Distal (>10kb) Multiome | 316 | |
| chr12:104,408,645–104,409,206 | 48.1 kb | Distal (>10kb) Multiome | 348 | |
| chr12:104,414,328–104,416,462 | 42.1 kb | Distal (>10kb) Multiome | 437 | |
| chr12:104,456,290–104,458,686 | 56 bp | At TSS Multiome | 684 | |
| chr12:104,458,922–104,459,079 | 2.0 kb | Proximal (<10kb) | 112 | |
| chr12:104,578,451–104,579,185 | 121.8 kb | Distal (>10kb) Multiome | 184 | |
| chr12:104,605,331–104,606,033 | 148.7 kb | Distal (>10kb) Multiome | 162 | |
| chr12:104,722,661–104,723,450 | 266.1 kb | Distal (>10kb) Multiome | 215 | |
| chr12:105,107,164–105,108,312 | 650.8 kb | Distal (>10kb) Multiome HiCAR | 1033 |
Genomic view of the CHST11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.