Enables Hsp90 protein binding activity. Predicted to be involved in several processes, including centrosome duplication; chaperone-mediated protein folding; and negative regulation of Rho-dependent protein serine/threonine kinase activity. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CHORDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHORDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHORDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:90,133,649–90,135,329 | 88.4 kb | Distal (>10kb) Multiome | 459 | |
| chr11:90,218,687–90,219,092 | 4.0 kb | Proximal (<10kb) | 61 | |
| chr11:90,222,376–90,223,604 | 3 bp | At TSS Multiome | 798 | |
| chr11:90,240,017–90,240,904 | 17.3 kb | Distal (>10kb) Multiome | 224 |
Genomic view of the CHORDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.