CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for CHMP1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHMP1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHMP1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:11,688,830–11,690,282 | 162.1 kb | Distal (>10kb) Multiome | 759 | |
| chr18:11,714,339–11,714,936 | 136.9 kb | Distal (>10kb) Multiome | 121 | |
| chr18:11,751,239–11,752,922 | 99.8 kb | Distal (>10kb) Multiome | 189 | |
| chr18:11,823,081–11,823,838 | 27.8 kb | Distal (>10kb) Multiome | 76 | |
| chr18:11,849,797–11,850,418 | 993 bp | At TSS | 503 | |
| chr18:11,850,966–11,851,799 | 50 bp | At TSS Multiome | 890 | |
| chr18:11,908,184–11,909,142 | 57.1 kb | Distal (>10kb) Multiome | 805 | |
| chr18:11,947,210–11,948,156 | 96.1 kb | Distal (>10kb) Multiome | 645 | |
| chr18:11,980,290–11,982,581 | 129.7 kb | Distal (>10kb) Multiome | 1002 | |
| chr18:12,038,383–12,039,391 | 187.7 kb | Distal (>10kb) Multiome | 700 | |
| chr18:12,076,413–12,076,882 | 225.2 kb | Distal (>10kb) Multiome | 129 |
Genomic view of the CHMP1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.