The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CHML. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHML upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHML, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:241,356,109–241,357,633 | 283.2 kb | Distal (>10kb) Multiome | 482 | |
| chr1:241,423,745–241,424,961 | 216.0 kb | Distal (>10kb) Multiome | 469 | |
| chr1:241,518,869–241,520,362 | 120.5 kb | Distal (>10kb) Multiome | 873 | |
| chr1:241,637,452–241,638,377 | 1.9 kb | Proximal (<10kb) | 193 | |
| chr1:241,639,451–241,641,575 | 139 bp | At TSS Multiome | 858 | |
| chr1:241,847,523–241,848,842 | 207.8 kb | Distal (>10kb) Multiome HiCAR | 920 |
Genomic view of the CHML locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.